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. Author manuscript; available in PMC: 2012 Feb 28.
Published in final edited form as: J Chem Inf Model. 2011 Feb 7;51(2):420–433. doi: 10.1021/ci100375b

Fig. 4.

Fig. 4

Superimposition of the nonselective 5-HT2B/2C receptor antagonist (SB-206533 1) and the selective 5-HT2B receptor antagonist (2) at the human 5-HT2B receptor. The N-methyl of the cyclohexa indole ring of 2 is closer to the upper part of TM3 leading to unfavorable interactions with bulkier Ile side chains in the 5-HT2C receptors (I132), while the methyl of the cyclopenta-indole ring in SB-206533 1 is pointing toward the upper TM 4.