Table 2.
Description of Probands (Cases/Controls) in Participating Studies
| Study | Full Study Name | No. | MI, % | Female Sex, % | Age, y | BMI | CAD Definition | Control Definition | Ref |
|---|---|---|---|---|---|---|---|---|---|
| ADVANCE | Atherosclerotic Disease, VAscular functioN, and genetiC Epidemiology | 278/312 | 50.4 | 57.9/59.0 | 45.8 (6.2)/45.3 (5.7) | 31.2 (7.1)/26.5 (5.7) | Clinical nonfatal CAD (men aged ≥45 years, women aged ≤55 years), including AMI (enzymes), typical angina with ≥1 artery with >50% stenosis, positive noninvasive test, or PCI or CABG | No history of clinical CAD, CVA, or PAD | 14 |
| CADomics | Coronary Artery Disease and Omics | 2078/2952 | 58.3 | 21.9/50.5 | 60.8 (10.1)/55.3 (10.8) | 29.4 (5.1)/27.0 (4.7) | CAD: >50% stenosis in 1 major coronary artery and/or MI based on ECG and enzymes | Population sample with no history of MI | − |
| CHARGE | Cohorts for Heart and Aging Research in | 2287/22 024 | 48.0 | 33.4/59.6 | 60.0 (7.9)/63.1 (8.0) | 28.1 (7.4)/27.5 (8.0) | CHD: definite or probable MI, PTCA or CABG, or ECG MI | None of the conditions that define CAD | 15 |
| decode | 6640/27 611 | 54.7 | 36.3/61.9 | 74.8 (11.8)/53.7 (21.5) | 27.7 (4.7)/27.0 (5.4)* | MI: MONICA criteria (aged <75 years) or discharge diagnosis of MI; CAD: PCI or participation in CVD genetics program with self-report of CABG or PCI or discharge diagnosis of angina pectoris, MI, or chronic ischemic heart disease | Population sample | 3 | |
| GERMIFS I | German Myocardial Infarction Family Studies I | 884/1604 | 100.0 | 49.4/50.8 | 50.2 (7.8)/62.6 (10.0)† | 27.4 (3.6)/27.7(4.5) | MI (<65 years) with >1 first-degree sibling with severe CAD (PTCA, MI, CABG) | Population sample | 4 |
| GERMIFS II | German Myocardial Infarction Family Studies II | 1222/1287 | 100.0 | 33.1/48.3 | 51.4 (7.5)/51.2 (11.9)† | 29.0 (3.8)/27.4 (4.6) | MI (aged <60 years); 59.4% with family history of CAD | Population sample | 6 |
| GERMIFS III (KORA) | German Myocardial Infarction Family Studies III (Cooperative Research in the Region of Augsburg) | 1157/1748 | 100.0 | 20.1/48.9 | 58.6 (8.7)/55.9 (10.7)† | 27.0 (3.6)/27.1 (4.5) | MI (aged <60 years); MONICA criteria | Population sample | − |
| LURIC/ AtheroRemo 1 | Ludwigshafen Risk and Cardiovascular Heath Study | 652/213 | 71.9 | 20.3/46.0 | 61.0 (11.8)/58.3 (12.1) | 27.7 (4.4)/27.4 (4.2) | Symptoms of angina pectoris, NSTEMI, STEMI, or >50% coronary stenosis | No coronary lesions or minor stenoses (<20%) | 16 |
| LURIC/ AtheroRemo 2 | Ludwigshafen Risk and Cardiovascular Heath Study | 486/296 | 79.0 | 23.4/48.6 | 63.7 (9.4)/56.4 (12.7) | 27.1 (3.8)/26.8 (4.0) | Symptoms of angina pectoris, NSTEMI, STEMI, or >50% coronary stenosis | No coronary lesions or minor stenoses (<20%) | 16 |
| MedStar | 874/447‡ | 48.1 | 33.0/54.6 | 48.9 (6.4)/59.7 (8.9) | 31.7 (6.8)/31.3 (7.9) | Angiography (≥1 coronary vessel with >50% stenosis); aged <65 years | Angiography normal, aged >45 years | 5 | |
| MIGen | Myocardial Infarction Genetics Consortium | 1274/1407 | 100.0 | 37.2/39.9 | 42.4 (6.6)/43.0 (7.8)† | 27.6 (5.2)/25.8 (4.4) | MI (men aged <50 years/women aged <60 years) | Hospital based, community based, or nested case-control | 5 |
| OHGS | Ottawa Heart Genomics Study | 1542/1455 | 61.6 | 24.1/48.0 | 48.7 (7.3)/75.0 (5.0) | 28.5 (4.9)/26.0 (4.0) | Angiographic (>50% stenosis) | Asymptomatic | 17 |
| PennCATH | 933/468 | 50.3 | 23.7/51.9 | 52.7 (7.6)/61.7 (9.6) | 29.8 (5.6)/28.9 (6.4) | Angiography (≥1 coronary vessel with >50% stenosis); aged <65 years | Angiography normal, men aged >40 years/women aged >45 years | 5, 18 | |
| WTCCC‖ | Wellcome Trust Case Control Consortium | 1926/2938 | 71.5 | 20.7/50.0 | 49.8 (7.7)‖ | 27.6 (4.2)‖ | Validated MI, CABG, PTCA, or angina with positive noninvasive testing; aged <66 years | Unselected | 1 |
Age and BMI data are presented as mean (SD). AMI indicates acute myocardial infarction; BMI, body mass index; CABG, coronary artery bypass graft; CHD, coronary heart disease; CVA, cerebrovascular accident; CVD, cardiovascular disease; MONICA, Multinational MONItoring of trends and determinants in CArdiovascular disease; NSTEMI, non–ST-segment elevated myocardial infarction; PTCA, percutaneous transluminal coronary angioplasty; STEMI, ST-segment elevation myocardial infarction; PAD, peripheral arterial disease; PCI, percutaneous coronary intervention.
Information on BMI in the deCODE study is available for 81.7% of the cases and 66.8% of the controls.
For cases, age at diagnosis; for controls, age at recruitment.
Cases, angiographic CAD (>50% stenosis in at least 1 vessel); controls, angiography normal or <10% stenosis in all vessels.
WTCCC controls comprise an equal number of subjects from the 1958 Birth Cohort and from the National Blood Service Donors. The latter were recruited in equal 10-year age bands from age 11 to 70 years. Additional phenotypes are not available for these controls.