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Proposed pathway of pyrrolysine biosynthesis by the products of pylB, pylC, and pylD from two molecules of lysine. Lysine is first used to make (2R, 3R) 3-methylornithine. After ligation to a second molecule of lysine, the terminal amine of the methylornithyl-εN-lysine intermediate is oxidized to an aldehyde. Spontaneous elimination of water forms pyrrolysine. Supporting data is described throughout the text.
