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. Author manuscript; available in PMC: 2011 Apr 4.
Published in final edited form as: Proteomics Clin Appl. 2008 Jul 24;2(9):1234–1245. doi: 10.1002/prca.200780103

Figure 8.

Figure 8

A summarized scheme highlights the benefits of a platform to vaccine and proteomics research. Once proteins are selected from genomics and/or proteomics, the vector-based vaccine system coupled to proteomic approaches and antigen microarrays expedites the detection of protein immunogenicities. Intranasal immunization with the vector-based vaccines liberates the dependence on adjuvants, protein purification and needles. The effectiveness of platform was demonstrated in this study by using two proteins (Tet-c and SLP), an E. coli vector (two different plasmids, pCAL-n-FLAG and pEcoli-Nterm 6xHN) and two mass spectrometers (MALDI-TOF MS and NanoLC-MS/MS).