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Tumor development, treatment, and CYP2D6 activity influence. Time courses for the prodrug plasma concentration (A) as well as viable tumor cells (B) are shown for five different values of CYP2D6 activity. Without CYP2D6 activity (magenta), no active metabolite will be generated. Regarding tumor growth, this scenario is identical to a scenario without drug treatment. The activity differences for CYP2D6 between PM, IM, EM, and UM were derived according to Zanger et al. (2001).
