TABLE 1.

Expression of an Elp3 HAT-defective mutant by embryonic GAL4 drivers

Gal4 driver of Elp3 HAT mutant	Phenotype
PtcGal4	Embryonic lethal
EngrailedGal4	Embryonic lethal
RhomboidGal4	Embryonic lethal
Actin5CGal4	Embryonic lethal
HairyGal4	Normal development
KruppelGal4	Normal development
ElavGal4	Normal development
MS1096Gal4	Deformed wings
Heat shock	Delayed development and pupal death

In a wild-type background, expression of an Elp3 HAT point-mutant typically results in lethality. Wing development is severely impaired when the mutant protein is expressed from a wing-specific driver (MS1096-GAL4) (see also Figure S1). Heat-shock induction of the mutant Elp3 at first and second instar stages caused a delay in development and death at late larval stages.