Table 2.
Tissue of Origin Test Clinical Validation Results
| Reference cancer diagnosis | Agreement % (ratio) | 95% CI | Nonagreement % (ratio) | 95% CI |
|---|---|---|---|---|
| Bladder | 79.3 (23/29) | 60.3–92.0 | 20.7 (6/29) | 8.0–39.7 |
| Breast | 96.5 (55/57) | 87.9–99.6 | 3.5 (2/57) | 0.4–12.1 |
| Colorectal | 91.7 (33/36) | 77.5–98.2 | 8.3 (3/36) | 1.8–22.5 |
| Gastric | 72.0 (18/25) | 50.6–87.9 | 28.0 (7/25) | 12.1–49.4 |
| Hepatocellular | 96.0 (24/25) | 79.6–99.9 | 4.0 (1/25) | 0.1–20.4 |
| Kidney | 89.3 (25/28) | 71.8–97.7 | 10.7 (3/28) | 0.3–28.2 |
| Melanoma | 84.0 (21/25) | 63.9–95.5 | 16.0 (4/25) | 0.5–36.1 |
| Non-Hodgkin's lymphoma | 89.7 (26/29) | 72.6–97.8 | 10.3 (3/29) | 2.2–27.4 |
| Non-small cell lung | 85.2 (23/27) | 66.3–95.8 | 14.8 (4/27) | 4.2–33.7 |
| Ovarian | 88.9 (40/45) | 75.9–96.3 | 11.1 (5/45) | 3.7–24.1 |
| Pancreas | 85.7 (24/28) | 67.3–96.0 | 14.3 (4/28) | 4.0–32.7 |
| Prostate | 96.0 (24/25) | 79.6–99.9 | 4.0 (1/25) | 0.1–20.4 |
| Sarcoma | 88.9 (24/27) | 70.8–97.6 | 11.1 (3/27) | 2.4–29.2 |
| Testicular germ cell | 84.0 (21/25) | 63.9–95.5 | 16.0 (4/25) | 4.5–36.1 |
| Thyroid | 90.3 (28/31) | 74.2–98.0 | 9.7 (3/31) | 2.0–25.8 |
| Overall | 88.5 (409/462) | 85.3–91.3 | 11.5 (53/462) | 8.7–14.7 |