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. 2011 Mar;178(3):1153–1166. doi: 10.1016/j.ajpath.2010.11.052

Figure 1.

Figure 1

β-Caryophyllene (BCP) ameliorates DSS-induced colitis. Mice received DSS (3%) for 5 days and drinking water for the next 2 days. Animals were orally treated by gavage with 12.5, 25, or 50 mg/kg of BCP twice a day from day 0 to day 7 (preventive treatment) or with 50 mg/kg from day 3 to day 7 (therapeutic treatment). Preventive or therapeutic oral treatment with BCP improved the disease activity index (DAI) score (A and B), reduced body weight loss (C) and colon macroscopic damage (D), and enhanced colon length (E), compared with mice from the DSS group. Data are reported as means ± SEM (n = 5 to 7 mice per group). *P < 0.05 versus the DSS-treated group; **P < 0.05 versus the control group; ***P < 0.05 versus the preventive BCP-treated group (50 mg/kg, p.o.). (F) Representative photographs of colons from control mice (CTL), DSS-treated mice, and preventive BCP-treated mice (50 mg/kg, p.o.).