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. 2011 Mar;178(3):1190–1200. doi: 10.1016/j.ajpath.2010.11.067

Figure 7.

Figure 7

Extended time to death but no protection after anti-LcrV treatment and neutrophil ablation in wild-type and Cxcr2−/− mice. A: Wild-type mice (n = 5) were given 100 μg anti-Gr-1 monoclonal antibody or PBS on days −1 and +1 postinfection and 400 μg anti-LcrV polyclonal antibody or PBS 60 minutes before intranasal infection with 4000 CFU Y. pestis CO92, and survival was monitored for a 14-day period. B: Percent daily weight loss compared to prechallenge weight is shown for all surviving mice in each group for the experiment shown in A. C:Cxcr2−/− mice (n = 5) were given 200 μg anti-Gr-1 or PBS 60 hpi and 400 μg anti-LcrV 60 minutes before inranasal infection with 4000 CFU Y. pestis CO92 and survival was monitored. *P < 0.05, **P < 0.005 as determined by Student's t-test.