Table 1.
Average Severity Score at 60 Hours Postinfection per Lung Sample
| Bacteria | Pathological lesion⁎ | Wild type + PBS | Cxcr2-/- + PBS | Cxcr2-/- + anti-LcrV |
|---|---|---|---|---|
| − | Neutrophil infiltration† | 1 (±1.00) | 1.67 (±0.44) | 0.33 (±0.44) |
| Alveolar destruction | 0 | 0 | 0 | |
| Pulmonary edema | 0 | 0 | 0 | |
| Parenchymal congestion | 0.13 (±0.19) | 1.5 (±1.00) | 0.67 (±0.44) | |
| + | Neutrophil infiltration† | NA | 2.50 (±0.67) | 2.00 (±0.00)‡ |
| Alveolar destruction | NA | 2.58 (±0.39)§ | 2.25 (±0.17)§ | |
| Pulmonary edema | NA | 1.17 (±0.56) | 1.50 (±0.33)‡ | |
| Parenchymal congestion | NA | 2.50 (±0.67) | 2.50 (±0.33)‡ |
Data are given ± the standard deviation from the mean; LcrV, low calcium response V-antigen; NA, not applicable; bacteria were not seen in any lobe.
⁎
Lesions observed and scored from H&E stain of formalin-fixed tissues.
†
Neutrophil enumeration from immunohistochemistry anti-Gr1 stain of formalin-fixed tissues.
‡
P<0.05;
§
P <0.001 compared to no bacteria of the same group; evaluated by Student's t-test.