The ocular and retinal structure and visual function of Wt and PEDF-Tg mice. A and B: The H&E-stained eye sections from 8-week-old Wt and PEDF-Tg mice. A: Ocular sections, 4×; scale bars = 200 μm. B: Retinal structure, 20×. The images were representatives from five mice of each type. C and D: ERG amplitudes of Wt and PEDF-Tg mice. Dark-adapted (scotopic/rod-associated) and light-adapted (photopic/cone-associated) ERGs were recorded from Wt and PEDF-Tg mice and the amplitudes of the A and B waves compared (mean ± SD, n = 6). GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium.