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. 2011 Feb;178(2):699–708. doi: 10.1016/j.ajpath.2010.10.008

Figure 2.

Figure 2

Injection with PCA-4248 decreases accumulation of different inflammatory cells in the dermis of K5.hTGF-β1 transgenic mice. The WT or K5.hTGF-β1 transgenic mice were injected i.p. twice weekly for 4 weeks with PCA-4248 (10 mg/kg) or its vehicle. Dorsal skin samples were collected at the end of the 4-week treatment regimen for assessment of inflammatory cell infiltrate. A: Representative images of immunohistochemically stained sections of CD68+ cells and CD3+ cells from the dorsal skin of a mouse from the different treatment groups. B: Evaluation of histologic or immunohistochemical sections included total inflammatory cell infiltrate (0, no; 1, mild; 2, moderate; and 3, severe) in the upper or lower dermis and number of neutrophils, CD68+ cells (monocytes/macrophages), and CD3+ T cells. Data shown are from one representative experiment, with n = 3 to 10 per treatment group. *P ≤ 0.05. **P ≤ 0.01. ***P ≤ 0.001. Error bars represent SEM.