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. 2011 Feb;178(2):699–708. doi: 10.1016/j.ajpath.2010.10.008

Figure 4.

Figure 4

Both PCA-4248 and PUVA decrease the PAF level in the skin of K5.hTGF-β1 transgenic mice. A: The PAF levels were analyzed in skin samples from WT or K5.hTGF-β1 transgenic mice injected with either PCA-4248 or its vehicle or transgenic mice treated with a subphototoxic (0.25 J/cm2) or near-phototoxic (0.50 J/cm2) dose of PUVA. Both PCA-4248 and PUVA significantly decreased the level of PAF in dorsal skin of the transgenic mice, as detected by means of mass spectrometry. Data shown are pooled from two independent experiments, with n = 3 to 7 per treatment group. *P ≤ 0.05. **P ≤ 0.01. ***P ≤ 0.001. B: Representative histogram of the results of mass spectrometric analysis of a sample from an individual K5.hTGF-β1 transgenic mouse injected with either vehicle or PCA-4248. PAF (18:1), peak of PAF; LPC (20:1), peak of lysophosphatidylcholine. Error bars represent SEM.