Immunohistological staining using the antibody to type I collagen (A) and antibody to F4/80 (B) in the cortex of Tg and WT control and AA-treated mice on day 5. Original magnification, × 200. On days 1, 3, and 5 in both groups, these areas were also assessed quantitatively (C and D), as described under Materials and Methods. Data are reported as means ± SE. *P < 0.05, compared with the control group on the same day; **P < 0.05, compared with the WT group on the same day; ***P < 0.05, compared with the same group on day 1; †P < 0.05, compared with the same group on day 3.