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Role of FXR in inflammation in the liver during cholestasis. Wild-type and farnesoid X receptor (FXR) knockout mice were subjected to BDL or sham operation. Three days later, mRNA levels of ICAM-1 (A) and MIP-2 (B) were quantified and hepatic neutrophil accumulation (C) was measured. Values significantly different (*P < 0.05) from sham-operated mice; and significantly different (**P < 0.05) from wild-type mice subjected to BDL.
