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. 2011 Mar;178(3):1270–1278. doi: 10.1016/j.ajpath.2010.11.063

Figure 1.

Figure 1

Hearing loss and impaired vibration of the malleus in osteopetrotic mice. A and B: Evaluation of the hearing threshold based on auditory brainstem response. Rankl−/− mice (A, open squares, aged 6 to 8 weeks, n = 6) and Fos−/− mice (B, open squares, aged 6 to 8 weeks, n = 6) were compared with wild-type controls (closed squares, aged 6 to 8 weeks, n = 6 for each). *P < 0.05 and **P < 0.001 versus wild-type controls. SPL indicates sound pressure level. C–E: Laser Doppler vibrometry. C: Picture of the experimental setting; sp, speaker. The pink arrow indicates the direction of the laser beam. D: The malleus (M) behind the tympanic membrane in a wild-type mouse targeted with the laser beam. E: Velocity of the vibrating malleus in littermate controls (n = 5), Rankl−/− mice (aged 17 weeks, n = 2), and Fos−/− mice (aged 10 to 14 weeks, n = 3) exposed to pure-tone sounds at 2, 4, 12, and 20 kHz. *P < 0.05 and **P < 0.01 versus controls.