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. 2011 Feb;178(2):853–860. doi: 10.1016/j.ajpath.2010.10.033

Figure 1.

Figure 1

Significant fraction of papillary renal cell carcinoma (PRCC) show increased hypoxic profile. A: Equal amounts of total cell lysates generated from type 1 or type 2 tumor tissue (T) and matching normal tissue (N) from surgical specimens of 15 patients with PRCC were immunoblotted with the indicated antibodies. B: Equal amounts of the total cell lysates generated from the indicated cell lines were resolved on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotted with the indicated antibodies. C: Equal amounts of the total cell lysates generated from CAKI-2, UMRC2, and UMRC2-VHL maintained in normoxia (21% O2: −) or hypoxia (1% O2: +) for 24 hours were resolved on SDS-PAGE and immunblotted with the indicated antibodies. VHL, von Hippel-Lindau.