Figure 6.

XB130 protein expression analysis with a thyroid tissue microarray. A: Immunohistochemistry staining with XB130 monoclonal antibody for normal thyroid, papillary carcinoma, and anaplastic/insular carcinoma (10×). Enlargement for selected areas as indicated is shown in the right column. Predominantly cytoplasmic staining was observed in normal thyroid tissue localized to thyroid follicular cells. B: Semiquantitative analysis of thyroid tissue microarray showed expression of XB130 in carcinoma samples at reduced levels. **P < 0.01 as compared to the normal group, ***P < 0.001 as compared to both the normal and benign lesion groups.