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. 2011 Mar 23;121(4):1313–1328. doi: 10.1172/JCI42405

Figure 1. H1975 and A549 NSCLC xenografts show different patterns of resistance to BV treatment.

Figure 1

(A and B) Tumor growth curves of H1975 (A; n = 5 per group) and A549 (B; n = 6 per group) xenografts receiving vehicle (control) and BV for 2 weeks. (C) Mean tumor volume obtained at the last measurement in H1975 and A549 xenografts treated with BV for 2 weeks compared with controls (ΔT/ΔC). *P < 0.05, Mann-Whitney test. (D and E) Individual tumor growth curves of H1975 (D; n = 6 per group) and A549 (E; n = 5 per group) xenografts treated with vehicle and BV until animals became moribund. Tumors were considered resistant (progression) when tripled in volume compared with the beginning of the treatment.