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. 2011 Mar 23;121(4):1313–1328. doi: 10.1172/JCI42405

Figure 4. Increase in stromal FGFR2 expression in H1975 BV-resistant xenografts.

Figure 4

(A) Representative IF images of CD31 and FGFR2 staining in H1975 vehicle- and BV-treated H1975 xenografts at progression, using confocal microscopy. At least 5 microphotographs were collected from 4 specimens per group. Original magnification, ×200. Scale bar: 20 μm. (B) Percent FGFR2+ fluorescent cells counted in 5 random microscopic fields (×200) per sample (n = 4 per group). *P < 0.001, t test. (C) bFGF levels were measured in plasma of vehicle- and BV-treated H1975 xenografts at progression, using multiplex bead assay (n = 4 per group; each sample tested in duplicate). P value was calculated using t test. (D) Representative IHC images showing bFGF protein expression in vehicle- and BV-treated H1975 xenografts. At least 5 random microscopic fields were collected from each of 4 specimens per group. Original magnification, ×200.