TABLE I.
Rash definitions according to the U.S. National Cancer Institute Common Terminology Criteria for Adverse Events, version 4 7
| Maculopapular rash | ||
| Definition | A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbilliform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally, and associated with pruritus. | |
| Grade 3 | Macules and papules covering more than 30% of the body surface area with or without associated symptoms; limiting self-care activities of daily living | |
| Grade 4 | Not stated | |
| Acneiform rash | ||
| Definition | A disorder characterized by an eruption of papules and pustules, typically appearing on the face, scalp, upper chest, and back. | |
| Grade 3 | Papules or pustules (or both) covering more than 30% of body surface area, which may or may not be associated with symptoms of pruritus or tenderness; limiting instrumental activities of daily living; associated with local superinfection, with oral antibiotics indicated | |
| Grade 4 | Papules or pustules (or both) covering any percentage of body surface area, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with intravenous antibiotics indicated; life-threatening consequences | |