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. 2011 Apr 4;6(4):e18323. doi: 10.1371/journal.pone.0018323

Figure 2. Dll4 expressed on BM-VPC stimulate a vascular activation and stabilization program on endothelial cells.

Figure 2

A. Genes differently expressed on HUVEC after co-cultered with BM-VPC-WT, BM-VPC-Dll4 or mDll4GOF BM-VPC. These results were obtained from one hybridization using pooled samples from 3 experiments. B. Expression of Hey2 and Hes1 in HUVEC co-cultured with mouse isolated BM-VPC in presence of mouse specific neutralizing antibody for Dll4 (mDll4i) or γ-secretase inhibitor (γSi). C. ICAM2, FN1 and VE-Cadherin expression in HUVEC co-cultured with mouse BM-VPC or BM-VPC in presence of mouse specific neutralizing antibody for Dll4 (mDll4i). D. ICAM2, FN1 and VE-Cadherin expression in HUVEC co-cultured with mouse BM-VPC-WT or MDll4GOF BM-VPC. Gene expression was quantified by RT-PCR in B,C and D. (values show the mean plus s.e.m. *: P<0.05).