Figure 7. Increased expression of Dll4 in circulating blood cells regulates vessel stability in early stages of tumor development.

A. Fibronectin 1 (FN1) and PECAM expression were detected by immunofluorescence. Scale bar indicates 50 µm B. FN1 staining quantification was performed using ImageJ. C. Vessel diameter was quantified measuring the smallest distance between two endothelial nuclei in opposing sides at more than 4 different vessel levels. D. Vessel density was obtained by counting the number of vessels per section. (values show the mean plus s.e.m. *: P<0.05).