Table 4. Adipocytokine Correlations with Metabolic Measures.

	BMI		Total Cholesterol		HDL-C		LDL-C		Triglycerides
	R2	Sig	R2	Sig	R2	Sig	R2	Sig	R2	Sig
Null	0.51		0.15		0.10		0.15		0.17
PC1	0.61	5×10−21	0.15	NS	0.11	NS	0.15	NS	0.17	NS
PC2	0.51	0.05	0.15	NS	0.11	NS	0.16	NS	0.17	NS
PC3	0.51	NS	0.15	NS	0.12	0.07	0.15	NS	0.18	0.02
Leptin	0.65	1×10−23	0.18	NS	0.11	NS	0.17	NS	0.17	NS
Insulin	0.54	0.0031	0.17	NS	0.13	0.04	0.17	NS	0.19	0.002
TNFα	0.53	NS	0.18	NS	0.11	NS	0.17	NS	0.16	NS
Adiponectin	0.52	0.0003	0.16	NS	0.12	0.06	0.15	NS	0.18	0.006
aPAI1	0.54	2×10−5	0.15	NS	0.09	NS	0.15	NS	0.16	NS
Resistin	0.51	NS	0.15	NS	0.11	NS	0.15	NS	0.17	NS
hsCRP	0.54	6×10−8	0.15	NS	0.13	0.02	0.16	NS	0.17	NS
ANG II	0.52	NS	0.15	NS	0.15	5×10−5	0.15	NS	0.19	NS

Note: Table shows percent variance explained (R²) by the full model including Cohort, Generation, Gender, and Age(Gender), as well as the indicated adipocytokine (or principal component) with BMI or metabolite levels, as well as the significance of the adipocytokine/PC term. The first row labeled Null is the model without an adipocytokine/PC, and shows the variance explained jointly by Cohort, Generation, Gender and Age (Gender) for comparison.