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Using a chiral stationary phase, HPLC traces of (+)-aR,11S-myricanol from M. cerifera (A) and commercially available (±)-myricanol (B) reveal 86% ee and 9% ee, respectively. Tau levels in HeLa-C3 cells are reduced significantly by enantiomerically-enriched (+)-aR,11S-myricanol but the racemic mixture showed no activity at similar concentrations (C & D).
