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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Cancer Res. 2011 Feb 11;71(7):2750–2760. doi: 10.1158/0008-5472.CAN-10-2954

Figure 2. PTEN expression is lost at all stages of melanoma progression.

Figure 2

(A) Images showing representative immunohistochemical staining of PTEN and (B) pAKT expression in a tissue array of nevi, atypical nevi, primary and metastatic melanoma patient tumor samples. 0-1 indicates no to low PTEN expression and +3 indicates the highest expression while +2-3 relates to high expression of pAKT. Magnification x 200. (C) Left panel shows percentage loss of PTEN expression in each subset of patient samples as indicated in blue while the right panel shows AKT activity in matched samples.