Figure 3.

The cohesion interaction network. Lines connecting proteins indicate known or potential interactions as derived from two proteomic databases and the literature. Cohesin and the loading factors are in yellow; additional proteins involved in cohesion or interacting with cohesin or the loading factors are in blue; all other proteins in the network are in white. Proteins outlined with boxes are part of macromolecular complexes. Prp11 is part of a complex in the spliceosomal pathway, and Apc2 is part of the anaphase-promoting complex (APC). Tid3p and Spc24 are both part of the spindle-pole body. Solid black lines indicate proteins that form dimeric interactions. The cohesion network of 17 proteins includes all those labeled, excluding Apc2, Tid4, Tid1 and Rad51.