. Author manuscript; available in PMC: 2012 Apr 4.

Published in final edited form as: Mol Pharm. 2011 Feb 15;8(2):621–628. doi: 10.1021/mp100446t

Table 1.

Experimental Design for longitudinal, multiplexed PET imaging of VEGF₁₂₁/rGel treatment efficacy, and ex vivo histopathology.

		Day 0	Day 1	Day 3	Day 7	Day 14
¹⁸F-FPPRGD2	Control	#	+ #	+ #	#	#
¹⁸F-FPPRGD2	VEGF₁₂₁/rGel	#	+ #	+ #	#	#
¹⁸F-FDG	Control	#	+ #	+ #	#	#
¹⁸F-FDG	VEGF₁₂₁/rGel	#	+ #	+#	#	#

¹⁸F-FMISO	Control	#	+ #	+ #	#	#
¹⁸F-FMISO	VEGF₁₂₁/rGel	#	+ #	+ #	#	#
18F-FLT	Control	#	+ #	+ #	#	#
18F-FLT	VEGF121/rGel	#	+ #	+ #	#	#

Histology		-	-	-	-	-

#, microPET imaging; +, Control Vehicle or VEGF₁₂₁/rGel treatment; −, Tumor tissue sampling; ¹⁸FFPPRGD2 and ¹⁸F-FDG PET imaging studies were performed on the same day with the same group of animals at 8 h interval (¹⁸F-FPPRGD2 PET first and ¹⁸F-FDG PET 8 h later); ¹⁸F-FMISO and ¹⁸F-FLT PET images were performed on the same day with the same group of animals (¹⁸F-FMISO PET first and ¹⁸FFLT PET 8 h later).