Figure 3.
Effect of nitric oxide (NO) on cell cycle progression in male and female vascular smooth muscle cells (VSMC). NO=DETA/NO 500 μmol/L and C=control. A-C) NO induced G0/G1 cell cycle arrest and decreased G2/M and S phase in male and female VSMC (#P<0.05 vs. same sex control; *P<0.05 vs. male control; +P<0.05 vs. male NO). However, the percent change is greater in males compared to females (τP<0.05 vs. percent reduction in males). Data shown are representative of five separate experiments; n = 3/treatment group.