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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Cancer Res. 2011 Feb 7;71(7):2488–2496. doi: 10.1158/0008-5472.CAN-10-2820

Figure 5. Local ablative RT endows TIDC with T-cell stimulatory capacity in WT mice but fails to generate functional TIDC in IFNAR KO mice.

Figure 5

a) CD11c+ cells were isolated from tumors (a) and draining lymph nodes (d) of 3 mice/group and pooled for analysis. Isolated CD11c+ cells were cocultured with naïve 2C T cells under various conditions and T cell proliferation assessed. Error bars represent the standard deviation among three triplicate wells. b,c) Cytokine concentrations in supernatents from in vitro culture with TIDCs. Levels of IFNγ (b) and TNFα (c) are shown (*p= 0.0192). Data shown are representative of two experiments with similar results. (Unless otherwise indicated ***p<0.001, **p<0.01; individual p values are available where noted above)