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Effect of exogenous IL-17 on mouse cartilage proteoglycan breakdown. Cartilage explants of patellae were pulse-labeled with 35S-sulfate for 3 h and incubated with IGF-1 (0.25 μg/ml), with or without IL-17 (10 or 100 ng/ml) and/or IL-1 (10 ng/ml) for 48 h. Cultures were performed with six patellae per variable, and data represent percentages of sulfate incorporation into proteoglycan ± SD relative to the values found with IGF-1 alone.
