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. Author manuscript; available in PMC: 2012 Apr 6.
Published in final edited form as: Cell Metab. 2011 Apr 6;13(4):469–475. doi: 10.1016/j.cmet.2011.03.001

Figure 1. Baseline studies in PTKO mice.

Figure 1

(A) 12-hour mean systolic BPs during the day (d) and at night (n) on a control diet. Systolic BPs were significantly lower in PTKO mice compared to controls (*p=0.03). (B) BPs increased significantly (†p<0.01) and to a similar extent in PTKO and controls during high salt (6% NaCl) feeding and returned to baseline values on low salt (<0.02% NaCl). BPs were significantly lower in the PTKOs throughout the experiment (*p<0.044). (C) The maximal increases in mean arterial pressure (MAP) compared to baseline in response to bolus infusions of angiotensin II (1 and 10 μg/kg) or epinephrine (10 μg/kg) were identical between PTKOs and controls. (D) Rates of fluid reabsorption by the renal PT measured in vivo using standard free flow micropuncture were significantly reduced in the PTKO mice compared to controls as an absolute rate (p=0.00011) or (F) when adjusted for single-nephron glomerular filtration rate (p=0.0007). Error bars represent SEM.