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. Author manuscript; available in PMC: 2012 Apr 6.
Published in final edited form as: Cell Metab. 2011 Apr 6;13(4):469–475. doi: 10.1016/j.cmet.2011.03.001

Figure 2. AT1A receptors in the proximal tubule promote hypertension.

Figure 2

(A) With infusion of ang II (1000ng/kg/min), BPs increased significantly in both control and PTKO mice but the hypertensive response to angiotensin II was significantly attenuated in the PTKOs (**p<0.001). (B) The mean increase in BP during the angiotensin II infusion was significantly less in the PTKOs (23±3 mm Hg) compared to controls (black bars; 38±5 mm Hg, *p=0.0005). (C) Cumulative sodium balance was significantly lower in the PTKOs (n=8) than controls (n=7, *p=0.046) during the first 3 days of ang II infusion. Error bars represent SEM.