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Physiological Data
| Control (n=8) | PT KO (n=7) | P Value | |
|---|---|---|---|
| Body weight (g) | 32.4 ± 1.73 | 30 ± 1.54 | ns |
| Kidney weight (mg) | 435.4 ± 19.8 | 410 ± 22.1 | ns |
| Glomerular Filtration Rate, GFR (μL/min) | 620±49 | 439±58 | 0.025 |
| U osm (mOsm/kgH2O) | 2441.4 ± 103 | 2165 ± 102 | 0.15 |
| UV (μl/min) | 1.5 ± 0.08 | 2.1 ± 0.17 | 0.005 |
| Proximal Tubule Micropuncture | |||
| TF/P iothal | 1.85 ± 0.05 | 1.6 ± 0.03 | 0.0002 |
| Absorption (nl/min) | 7.5 ± 0.58 | 4.76 ± 0.32 | 0.000 |
| Fractional Abs (%) | 44.45 ± 1.57 | 36.5 ± 1.53 | 0.0005 |
Data represent values ± SEM.
