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. 2011 Feb 2;36(5):1104–1113. doi: 10.1038/npp.2010.248

Figure 5.

Figure 5

(Left panel) Effects of 0.1 mg/kg cocaine (C), quinpirole (Q), and PG 619 (N-(3-hydroxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide HCl) (PG) administered alone (open symbols) to reinstate cocaine seeking. (Right panel) Effects of PG 619 (0.03–1.0 mg/kg) and quinpirole (0.1 mg/kg) to attenuate cocaine-induced reinstatement when administered 10 min before 0.1 mg/kg cocaine (filled symbols). Data are represented as mean±SEM percent cocaine-prime responding. Asterisks (***p<0.001) indicate statistical difference from cocaine-elicited responding.