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. Author manuscript; available in PMC: 2011 Apr 5.
Published in final edited form as: Toxicol Pathol. 2008 Dec;36(7):142s–163s. doi: 10.1177/0192623308327117

FIGURE 4.

FIGURE 4

Three syndromes of ovary-dependent dysregulation of the endometrium. (A–C) Abnormal endometrial bleeding in a pubertal macaque; note the absence of a corpus luteum (A) and hemorrhage in the functionalis without prior luteal differentiation (B). In panel (C), the absence of subnuclear vacuoles or stromal decidualization indicate that the bleeding is out of cycle. (D–F) Suppression of ovarian function in a 21.5-year-old cynomolgus monkey, with quiescent ovarian and endometrial morphology. (G–I) Polycystic ovarian syndrome in a thirteen-year-old cynomolgus monkey, characterized by polycystic ovaries and endometrial hyperplasia. This pattern should not be confused with (A).