Table 1. Total body weight of the four groups at baseline and after 1 week therapy.

	Control (no 3-VO, n=8)	Vehicle (n=9)	Leptin (n=10)	GM-CSF (n=10)
Weight before 3-VO (g)	320±6	316±8	317±6	315±0
Weight after 1 week (g)	320±2	298±12 (−5.7%)	275±6* (−13%)	307±10 (−2.5%)

3-VO, three-vessel occlusion; GM-CSF, granulocyte–macrophage colony stimulating factor.

Percent change in body weight is indicated in parentheses. Leptin treatment significantly reduced total body weight compared with baseline values before treatment (^*P<0.001).