Table 2. Comparison among AUCs derived from the analysis using all ROIs across all seven patients (Cambridge data set).

Penumbra thresholda	AUC		MTT threshold		Comparison	Zb
	AUC	CI	OT	90%-T
Classic
MTT Abs	0.81	0.76–0.85	7.8 seconds	8.6 seconds	Abs versus delay	0.56
MTT delay	0.79	0.74–0.84	2.8 seconds	4.3 seconds	Abs versus ratio	0.52
MTT ratio	0.79	0.75–0.83	151%	214%	Delay versus ratio	0.06
Normalized
MTT delay	0.89	0.84–0.94	4.3 seconds	5.2 seconds
MTT ratio	0.89	0.85–0.94	186%	223%	Delay versus ratio	0.15
Stringent
MTT Abs	0.84	0.79–0.90	8.1 seconds	9.5 seconds	Abs versus delay	0.68
MTT delay	0.82	0.77–0.86	2.8 seconds	5.4 seconds	Abs versus ratio	1.28
MTT ratio	0.79	0.76–0.88	169%	232%	Delay versus ratio	0.55

Abs, absolute; AUC, area under the curve; CI, confidence interval; MTT Abs, absolute MTT value; OT, optimal threshold; 90%-T, 90% specificity threshold (see text); ROI, region of interest.

^aSee the ‘Methods' section for details.

^bZ-scores <1.96 are not statistically significant.