Figure 4.

Time to change in tropism from CCR5-using (R5) to dual/mixed (DM) or X4 virus in maraviroc arms. The change in tropism in the maraviroc arms, where all patients had R5 virus identified at screening by Trofile and switched tropism to DM or X4 over the course of the studies, according to the Trofile assay. Light gray and dark gray lines correspond to genotyping R5 (n = 605) and non-R5 (n = 135) groups, respectively, whereas the thinner solid black line corresponds to the Trofile R5 (n = 740) group. HIV, human immunodeficiency virus. Geno, genotypic tropism result by deep sequencing.