Table 3.

Associations between the Top 20 SNPs^* and Early Onset (≤55 Years) of EA.

SNP	Reference Genotype	Gene	Pathway	AOR (95% CI)†	P†	FDR†
rs2070744	CC	NOS3	Carcinogen/procarcinogen metabolism	1.76 (1.25–2.48)	.001	0.01
rs2236302	CC	MMP14	Metastasis	0.27 (0.12–0.61)	.002	0.01
rs720321	GG	BCL2	Apoptosis	0.40 (0.23–0.72)	.002	0.01
rs4740363	AA	ABL1	Cell cycle control	0.16 (0.05–0.53)	.003	0.01
rs11775256	CC	TNFRSF10A	Apoptosis	1.79 (1.20–2.68)	.004	0.02
rs17757541	CC	BCL2	Apoptosis	0.45 (0.26–0.78)	.005	0.02
rs696217	GG	GHRL	Cell growth	0.27 (0.10–0.71)	.008	0.02
rs1035142	GG	CASP8	Apoptosis	0.61 (0.42–0.89)	.010	0.02
rs2445762	CC	CYP19A1	Carcinogen/procarcinogen metabolism	1.63 (1.11–2.41)	.014	0.03
rs11941492	CC	VEGFR2/KDR	Angiogenesis	1.58 (1.07–2.32)	.020	0.04
rs4149570	GG	TNFRSF1A	Apoptosis	1.46 (1.02–2.08)	.037	0.07
rs1110277	GG	SLC23A2	Molecular transport	1.48 (1.01–2.16)	.04	0.07
rs11244142	AA	ABL1	Cell cycle control	1.63 (1.01–2.63)	.04	0.07
rs11196422	GG	CASP7	Apoptosis	1.55 (0.97–2.47)	.06	0.09
rs6097809	TT	CYP24A1	Carcinogen/procarcinogen metabolism	1.87 (0.88–3.99)	.10	0.14
rs1234220	TT	PTEN	Apoptosis	1.60 (0.87–2.94)	.13	0.16
rs640180	GG	FGFR4	Angiogenesis	1.34 (0.90–2.00)	.15	0.17
rs1801265	CC	DPYD	Carcinogen/procarcinogen metabolism	1.33 (0.86–2.05)	.20	0.22
rs3808815	CC	ABL1	Cell cycle control	1.33 (0.74–2.38)	.34	0.35
rs543215	AA	PGR	Sex hormone signaling	0.10 (0.61–1.56)	.93	0.93

^*Twenty SNPs that have the highest importance scores and lowest classification error rate were identified by random forest from among 1330 functional/tagging SNPs in 14 pathways.

^†Adjusted odds ratio used patients younger than 55 years as the reference; adjusted for sex, BMI at age 18 years (<25 vs .25), GERD (+/-), and smoking (never/ever); FDR < 0.05 was defined as significant.