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CD1d−/− mice and major histocompatibility complex (MHC) class II−/− mice are more resistant than wild-type mice to intradermal infections by Trypanosoma congolense. Groups of 10 wild-type C57BL/6 mice (A), CD1d−/− C57BL/6 mice (B), or MHC class II−/− C57BL/6 mice (C) were infected intradermally with 104 T. congolense, clone TC13. Parasitemia was monitored after infection. Infected CD1d−/−mice (P < .00001) and MHC class II−/− mice (P < .001) showed no or significantly less parasitemia.
