Table 3.
The Increased Risk for Mortality Conferred by Higher sCD14 Levels Does Not Differ between Treatment Arms
| Drug conservation arm |
Viral suppression arm |
||||
| Biomarker | OR (95% CI)a | P | OR (95% CI) | P | P for interaction |
| sCD14 level, ×106 pg/mL | 3.5 (1.5–8.3) | .004 | 2.0 (0.8–5.4) | .15 | .43 |
| LPS, pg/mL | 1.0 (0.6–1.7) | .96 | 0.7 (0.3–1.7) | .40 | .63 |
| I-FABP, pg/mL | 0.9 (0.4–2.1) | .84 | 2.3 (0.6–8.8) | .19 | .58 |
| 16S rDNA, copies/μL | 0.9 (0.4–2.2) | .90 | 0.5 (0.2–1.4) | .21 | .26 |
| EndoCAb, MMU/mL | 1.1 (0.8–1.6) | .49 | 0.9 (0.6–1.4) | .66 | .57 |
NOTE. No biomarker other than sCD14 was associated with mortality in either treatment arm. CI, confidence interval; EndoCAb, endotoxin core antibody; I-FABP, intestinal fatty acid binding protein; LPS, lipopolysaccharide; OR, odds ratio; rDNA, ribosomal DNA; sCD14, soluble CD14.
OR based on univariate analysis derived from conditional logistic model, associated with a one interquartile range higher level of biomarker after log10 transformation.