Table 3.
P Values for Single-nucleotide Polymorphism (SNP) Associations for Top 5 SNPs in Genome-wide Association Study (GWAS)
| Top 5 SNPs in GWAS |
P values for SNP associations |
|
| GWAS P value | Adjusted P valuea | |
| rs4713462 | 1.9 × 10−6 | .02 |
| rs4713460 | 2.4 × 10−6 | .03 |
| rs2247056 | 1.4 × 10−5 | .07 |
| rs2853935 | 1.4 × 10−5 | .06 |
| rs2523535 | 2.2 × 10−5 | .11 |
NOTE. The HLA-B alleles HLA-B*2705, *5101, *5701, *0801, and *4501 together explain most of the genome-wide association signals detected in the region. Results are shown for the 5 most associated SNPs in the analysis of Gag-specific responses in white participants. All linear regression models include age, adenovirus serotype 5 titers, laboratory (HIV Vaccine Trials Network vs Merck), and EIGENSTRAT values as covariates.
a
The adjusted P value is obtained for each SNP in a model in which the 5 HLA-B alleles are incorporated.