Figure 2.

Nontypeable Haemophilus influenzae (NTHi) amoxicillin resistance in chinchilla model of otitis media. Chinchillas were infected with either ∼10³ colony-forming units (CFUs) of NTHi 86-028NP or NTHi 86-028NP bla on day 0. On days 4, 5, and 6, animals were treated with either 20 μg of amoxicillin (white squares) or sterile phosphate-buffered saline (PBS) (black circles) directly into the middle ear. All animals were harvested on day 7 after infection. The left half of the graph represents counts from the effusion (planktonic bacteria); the right half is from bullar homogenates (biofilm/tissue-associated bacteria). The long dashed line represents the limit of detection. The short lines represent the mean CFUs for each group.