Table 2.

Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax and HTLV-1 Basic Leucine Zipper–Specific CD8⁺ and CD4⁺ T Cell Responses in HTLV-1–Infected Subjects

		CD8+ T cell IFN-γ responsesb		CD8+ T cell IL-2 responsesb		CD4+ T cell IFN-γ responsesb		CD4+ T cell IL-2 responsesb
Subjects	VLa	Tax	HBZ	Tax	HBZ	Tax	HBZ	Tax	HBZ
HAM
TCG	7.69	45	14	0	0	232	0	210	0
TAL	46.15	46	0	44	0	19	4	16	9
TCL	6.7	295	0	39	0	5	0	0	0
TCO	4.91	0	0	2	0	31	0	17	0
TBU	3.12	111	0	2	0	21	12	12	0
TCQ	13.79	0	0	2	9	23	5	17	0
TBO	13.87	763	0	30	0	5	0	0	0
TAA	6.87	814	0	7	0	0	0	0	0
TCF	7.17	24	0	4	0	0	0	0	0
TBW	15.83	7	3	10	3	15	0	46	14
Median	7.17	79	-c	7	-c	20	5	17	-c
AC high
HCH	9.5	0	0	0	0	63	0	0	0
HEZ	5.1	80	0	0	0	5	4	5	4
HES	11.4	44	81	0	0	18	0	7	7
HEI	3.4	0	20	0	0	4	0	17	6
HBX	11.25	0	0	0	0	64	27	15	5
HDR	1.92	77	17	0	0	0	3	9	0
HCP	11.72	0	0	0	0	0	0	0	0
HAY	8.58	0	0	0	0	0	0	6	0
HBT	2.44	292	0	13	0	17	0	2	0
HBE	7.88	5	0	1	0	0	0	0	0
Median	8.23	77	20	-c	NDd	5	4	6	6
AC low
HBA	0.001	0	19	0	6	0	0	0	0
HDH	0.13	97	0	0	0	0	0	0	0
HDN	0.72	177	0	5	5	18	7	12	33
HBV	0.01	0	0	78	0	8	0	43	8
HAE	0.03	17	23	0	0	26	2	0	0
HCL	0.17	246	3	53	5	0	0	4	0
HFL	0.1	2	2	0	0	0	0	0	2
HX	0.09	0	0	0	0	0	0	0	1
HAD	0.47	277	70	87	7	22	21	5	0
HDT	0.23	0	0	0	0	7	0	7	8
Median	0.115	137	19	66	6	18	7	7	8

NOTE. IFN, interferon; IL, interleukin; HAM, HTLV-1-associated myelopathy; AC, asymptomatic HTLV-1 carriers; HBZ, HTLV-1 basic leucine zipper.

^aData presented as spot-forming cells per 1E5 CD8 or CD4 T cells for each cytokine measured.

^bViral load is presented as HTLV-1 Tax DNA copies per 100 PBMCs.

^cNo median value calculated.

^dNot detected.