Table 4.
Median Frequency and Range of Tax- or HBZ-Specific CD8+ and CD4+ T Cells
| Tax |
HBZ |
|||||||
| CD8 |
CD4 |
CD8 |
CD4 |
|||||
| IFN-γ | IL-2 | IFN-γ | IL-2 | IFN-γ | IL-2 | IFN-γ | IL-2 | |
| HAM (n = 10) | 79 (7–814) | 7 (2 - 44) | 20 (5–232) | 17 (12–210) | -a (3 and 14) | -a (3 and 9) | 5 (4–12) | -a (9 and 14) |
| AC high (n = 10) | 77 (5–295) | -a (1 and 13) | 5 (4–46) | 6 (2–17) | 20 (17–81) | NDb | 4 (3–27) | 6 (4–7) |
| AC low (n = 10) | 137 (2–277) | 66 (5–87) | 18 (7–26) | 7 (4–43) | 19 (2–70) | 6 (5–7) | 7 (2–21) | 8 (1–33) |
| All participants (n = 30) | 80 (2–814) | 10 (1–87) | 18 (4–232) | 12 (2- 210) | 18 (2–81) | 6 (3–9) | 7 (2–27) | 7 (1–33) |
| HAM (n = 10) | 79 (7–814) | 7 (2 - 44) | 20 (5–232) | 17 (12–210) | -a (3 and 14) | -a (3 and 9) | 5 (4–12) | -a (9 and 14) |
| AC (n = 20) | 80 (2 -295) | 33 (1–87) | 28 (4–46) | 7 (2–43) | 20 (2–81) | 6 (5–7) | 6 (2–27) | 6 (1–33) |
| HVLc patients (n = 20) | 77 (5–814) | 7 (1–44) | 19 (4–232) | 15 (2–210) | 19 (3–81) | 6 (3–9) | 5 (3–27) | 7 (4–14) |
| LVLd patients (n = 10) | 137 (2–277) | 66 (5–87) | 18 (7–26) | 7 (4–43) | 19 (2–70) | 6 (5–7) | 7 (2–21) | 8 (1–33) |
NOTE. HBZ, HTLV-1 basic leucine zipper; IFN, interferon; IL, interleukin; HAM, HTLV-1-associated myelopathy; AC, asymptomatic HTLV-1 carriers; HVL, high viral load; LVL, low viral load.
Median frequency and in parenthesis the range of frequencies
a
No median value calculated.
b
Not detected.
c
HVL: High viral load patients with viral load more than 1%, which includes patients with HAM and AC.
d
LVL: Low viral load patients with viral load less than 1% and only includes asymptomatic carriers.