Haplotype of kindred surrounding the ALMS1 region. Arrow indicates the index case. Males and females are indicated by squares and circles, respectively; blackened circles and squares represent affected individuals; gray shading indicates a possible case of Alström syndrome with infantile congestive heart failure, but no other genetic or clinical information is available. Slash indicates deceased individuals from whom DNA was not available. Both affected individuals share a common haplotype defined by markers 16770, D2S210, D2S1394, D2S2111, D2S2109 and D2S286.