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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Nat Genet. 2011 Jan 23;43(3):189–196. doi: 10.1038/ng.756

Figure 5. In vivo modeling of TTC21B genetic interaction with other ciliopathy loci.

Figure 5

ttc21b interacts genetically with all loci known to contribute to disease in our ciliopathy cohort including bbs1, bbs2, bbs4, bbs6, bbs7, bbs10, bbs12, tmem216, nphp4, cc2d2a, rpgrip1l, mks1, and cep290 (see Table 1). Co-injection of a subeffective dose of ttc21b morpholino with any other single ciliopathy morpholino markedly exacerbates either the overall penetrance of gastrulation phenotypes (in comparison to the same doses injected alone) or a specific severity class.