Table 3.
Univariate analysis for factors associated with genotoxicity assays performed with urine extracts on HepG2 cells: statistical significance of associations (N = 64).
| Independent variables | P-value | |
|---|---|---|
| Tail DNA percent | MNi/1000 BNed | |
| Socio-demographic characteristics | ||
| Marital status (married/not married) | 0.12 | 0.94 |
| Smoking (ex-smokers/never smokers) | 0.16 | 0.18 |
| Educational level; years (> 12/≤ 12) | 0.04 | 0.23 |
| Age; years (≤ 39/> 39) | 0.01 | 0.02 |
| Alcohol consumption (regularly/occasionally) | 0.09 | 0.05 |
| Vegetable intake (usually/sometimes) | 0.05 | 0.02 |
| VOCs | ||
| Benzene | 0.01 | 0.001 |
| Toluene | 0.14 | 0.004 |
| Ethylbenzene | 0.01 | 0.001 |
| M+P-Xylene | 0.002 | < 0.001 |
| O-Xylene | 0.003 | < 0.001 |
| 1, 2,4 Trimethylebenzene | 0.02 | < 0.001 |
| Undecane | 0.05 | < 0.001 |
| Trichloroethylene | 0.07 | 0.05 |
| Tetrachloroethylene | 0.01 | 0.19 |
| Styrene | 0.09 | 0.002 |
| Decane | 0.001 | < 0.001 |
| 1,4 Dichlorobenzene | 0.06 | 0.02 |
| PAHs | ||
| Benzo(a)pyrene | 0.40 | 0.35 |
| Anthracene | 0.02 | 0.17 |
| Benz(a)anthracene | 0.20 | 0.20 |
| Benzo(b)fluoranthene | 0.16 | 0.22 |
| Benzo(g,h,i)perylene | 0.09 | 0.22 |
| Benzo(k)fluornathene | 0.21 | 0.24 |
| Chrysene | 0.01 | 0.03 |
| Dibenz(a,h)anthracene | 0.02 | 0.51 |
| Fluoranthene | 0.04 | 0.06 |
| Indeno(1,2,3-cd)pyrene | 0.08 | 0.20 |
| Phenanthrene | 0.01 | 0.03 |
| Pyrene | 0.03 | 0.11 |
| Benzo(j)fluoranthene | 0.06 | 0.26 |
| Total [B(a)P]eq | 0.15 | 0.34 |
Total [B(a)p]eq, total Benzo(a)pyrene equivalent concentration
MNi, micronuclei
BNed; binucleated cells