Table 3.
Cox multivariate regression analysis of PINCH expression at tumour invasive margin, sex, age and stage in poorly differentiated tumours in relation to patient survival in colorectal cancer
| Variable | N (%) | Death (%) | HR | 95% CI | P-value |
|---|---|---|---|---|---|
| PINCH expression | |||||
| Weak | 50 (55) | 30 (60) | 1.00 | - | - |
| Strong | 41 (45) | 36 (88) | 1.90 | 1.14-3.16 | 0.013 |
| Sex | |||||
| Male | 48 (53) | 34 (71) | 1.00 | - | - |
| Female | 43 (47) | 32 (74) | 1.10 | 0.67-1.81 | 0.69 |
| Age (years) | |||||
| ≤ 69 | 51 (56) | 40 (78) | 1.00 | - | - |
| > 69 | 40 (44) | 26 (65) | 1.37 | 0.81-2.32 | 0.24 |
| Stage | |||||
| I+II | 18 (20) | 7 (39) | 1.00 | - | - |
| III | 38 (42) | 26 (68) | 2.75 | 1.16-6.56 | 0.022 |
| IV | 35 (38) | 33 (94) | 9.09 | 3.63-22.75 | < 0.0001 |
HR: Hazard ratio; 95% CI: 95% confidence interval. (69 years = median age at operation)